|
KMID : 0606320040210010109
|
|
Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.21 No. 1 p.109 ~ p.113
|
|
|
파골세포 분화에 관여하는 Phosphodiesterase isozyme의 규명
|
|
Cho Eun-Sook
Yim Mi-Jung
|
|
|
Abstract
|
|
|
|
Phosphodiesterases (PDEs) are enzymes that degrade intracellular CAMP and Cgmp. In the present study, inhibition of PDE4 was demonstrated to influence osteoclast formation in co-cultures of mouse bone marrow cells and calvarial osteoblasts. Furthermore, PDE4 was shown to modulate Mrna expression of EP4, TRANCE, and COX-2 in calvarial osteoblasts. These results suggest that PDE4 is a key regulator of EP4, TRANCE, and COX-2 expression in osteoblasts, which in turn controls osteoclast formation.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|